Microvascular transplantation of physeal allografts

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Microvascular transplantation of physeal allografts.

We compared growth in vascularised allograft transplants, autografts and in non-operated physes in rabbits immunosuppressed with cyclosporin A and in non-immunosuppressed animals. Molecular haplotyping was undertaken before operation to ensure allogenicity. Postoperative bone scans and fluorochrome labelling were used to confirm physeal vascularity. The animals were killed at three or five week...

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Preservation of Talus Allografts for Clinical Transplantation

The osteochondral lesion of the talus and its treatment has become an important issue over last decades. The main causes of lesion of the talus cartilage are osteochondritis dissecans, arthritis, fractures, etc. There are many operative management techniques of the cartilage repair including bone marrow cell inducing techniques such as micro fracture surgery, drilling, PDGF and graft applicatio...

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Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy.

FK506 (Tacrolimus) recently has been shown to be an effective immunosuppressant after renal transplantation. It is associated with less hypertension, hypercholesterolemia and steroid use compared with cyclosporine. We report 10 patients on FK506 who showed fibrin thrombi within the glomerular capillaries and/or arterioles at renal allograft biopsy. These biopsies were generally performed to ass...

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Microvascular Disease After Renal Transplantation.

BACKGROUND/AIMS Individuals who reach end-stage kidney disease (CKD5) have a high risk of vascular events that persists even after renal transplantation. This study compared the prevalence and severity of microvascular disease in transplant recipients and patients with CKD5. METHODS Individuals with a renal transplant or CKD5 were recruited consecutively from renal clinics, and underwent bila...

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Bioengineering and characterization of physeal transplant with physeal reconstruction potential.

Damage to physes is of serious consequences in children. Currently available treatments are limited and results are unpredictable. In this study, we attempted to treat proximal tibial physeal damage in rabbits with transplanted bioengineered physeal tissue. Resting chondrocytes from the reserve zone of costal cartilages of 6-week-old rabbits were pellet cultured in centrifuge tubes. The pellets...

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ژورنال

عنوان ژورنال: The Journal of Bone and Joint Surgery. British volume

سال: 1995

ISSN: 0301-620X,2044-5377

DOI: 10.1302/0301-620x.77b5.7559716